HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments.

All statistical analyses were performed using the IBM SPSS 20; and p < 0.05 was considered significant and marked as *, # or $ for comparisons among different groups; p < 0.01 and p < 0.001 were both considered highly significant and marked as ** and ***, respectively.

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