Thermal proteome profiling reveals <i>Haemonchus</i> orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868.

We employ this worm species, because 1) it is a highly significant, pathogenic nematode with a high reproductive index, and can be readily maintained in a laboratory environment; 2) it represents one of the largest groups (clade V) of socioeconomically relevant nematodes of animals, including a range of species parasitic in humans; 3) it is relatively closely rela

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