Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles.

BMC Cancer · 2022 · PMC9617343 · PMID 36309655

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highly significantP < 0.01actually significant

HepG2 cancerous cells treated with the IC 50 dose of APT-VRM NPs recorded highly significant up-regulation ( P < 0.01) in the FADD gene expression (4.5 fold increase) and highly significant down-regulation ( P <0.01) in the c-FLIP gene expression (0.11 fold decrease) compared to the control (1), as shown in Fig. 2 A.

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