CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.

Nat Commun · 2022 · PMC9617877 · PMID 36309522

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highly significantno p-value reported

To determine if drug combinations displayed synergistic effects, we generated surface plots based on the Bliss independence model and found highly significant synergy (Bliss synergy score > 10) in both A375 and Colo829 cells (Fig. 5b, c ).

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