Plasma biomarkers inclusive of α-synuclein/amyloid-beta40 ratio strongly correlate with Mini-Mental State Examination score in Parkinson's disease and predict cognitive impairment.

Anti-α-synuclein ( b = 0.186; P = 0.048) was borderline significant, and α-synuclein/Aβ40 ( b = 0.015; P = 0.006) was the only significant biomarker for predicting cognitive impairment in PD group (M2; Table 4 ).

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In the PD group, biomarkers α-synuclein, anti-α-synuclein, α-synuclein/Aβ40 and anti-α-synuclein/Aβ40 were highly significant in a full model and parsimonious model: with R 2 = 0.838 and 0.835, respectively, compared to non-significant results in the VaD group ( R 2 = 0.149) and in the normal control group ( R 2 = 0.056).

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