Pharmacogenetics of Dolutegravir Plasma Exposure Among Southern Africans With Human Immunodeficiency Virus.

J Infect Dis · 2022 · PMC9624457 · PMID 35512135

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of borderline significanceno p-value reported

Including genotype in the population pharmacokinetic model Among the 41 intensively sampled individuals, 26 (8 with C/C, 10 with C/T, 8 with C/T) had UGT1A1 rs887829 genotype information and when this was tested on dolutegravir clearance, there was a graded trend towards reduced clearance for C/T and T/T individuals of borderline significance.

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