Interestingly, two different models of unpredictable chronic mild stress and Flinders Sensitive Line all showed decreases in 2-AG in the hippocampus ( 19 , 32 , 33 ), suggesting an overall trend toward decreased 2-AG in rodent models of depression. 2-AG is largely understudied in epilepsy, with one study of absence seizures in Genetic Absence Epilepsy Rat from Strasbourg (GAERS) reporting an increase in 2-AG ( 34 ) and another study in patients with MTLE reporting a decrease ( 27 ).
← all excerpts
Commonalities for comorbidity: Overlapping features of the endocannabinoid system in depression and epilepsy.
1
—
—