Genetic architecture of Parkinson's disease subtypes - Review of the literature.

And while LRRK2 neuropathology typically reflects “usual” PD pathology, with prominent synuclein inclusions and nigral cell loss, there may be significant variability in neuropathological findings leading some patients to be reclassified atypical PD despite having usual clinical presentations ( Uitti et al., 2004 ).

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