COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection.

PLoS Genet · 2022 · PMC9632821 · PMID 36327221

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In a stepwise regression approach using summary meta-analysis data for both traits, we found a highly significant overlap between genetic association signals (overlapped N SNP = 4,720); importantly, the SLE risk alleles were protective against severe COVID-19.

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