Inflammation mediates approximately one quarter of excess relative all-cause mortality in persons with rheumatoid arthritis: the Trøndelag Health Study.

However, the HR for RA fell from 1.34 in the Step2a model to 1.25 and RA was now barely significant (p = 0.048), consistent with the hypothesis that inflammation as captured by CRP may be a mediator of the increased mortality associated with RA.

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