Changes in bone turnover markers in patients without bone metastases receiving immune checkpoint inhibitors: An exploratory analysis.

J Bone Oncol · 2022 · PMC9633734 · PMID 36338920

Europe PMC DOI

hedged sentence

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

a decreasing trendp = 0.073so close (0.05 < p ≤ 0.1)

We found a significant increase of CTX-I levels after 3 months of ICIs treatment (mean T0 0.388 ± 0.037 μg/L vs T1 0.455 ± 0.042 μg/L; p = 0.045), while we observed a decreasing trend towards the reduction of PINP levels (mean T0 3432 ± 123 pg/ml vs T1 3256 ± 169 pg/ml; p = 0.073) ( Fig. 1 A and B).

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