Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis.

Front Immunol · 2022 · PMC9634083 · PMID 36341389

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an increasing trendno p-value reported

Although we observed an increasing trend of serum Lcn-2 levels in MS patients compared to HDs ( Figure 4A ), fecal rather than serum Lcn-2 levels were significantly associated with MS ( Figures 4B, C ).

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a decreasing trendno p-value reported

We also observed a decreasing trend in serum acetate (a short-chain fatty acid) levels in MS Lcn-2-high patients compared to HDs.

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