Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis.

Proc Natl Acad Sci U S A · 2022 · PMC9636955 · PMID 36282915

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highly significantno p-value reported

IPA identified β-estradiol as a highly significant upstream regulator of genes expressed in the Rest f/f Amhr2 Cre/+ cKO, showing an activation of estrogen receptor signaling in the absence of REST.

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