Cyp24a1 expression was suppressed by YKL-05-099 almost as effectively as PTH; however, the SK-124 failed to reach significance in its suppression of Cyp24a1 in this experiment, at this time point.
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Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules.
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