Artemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against <i>Pseudomonas aeruginosa</i> by inhibiting mRNA expression of aminoglycoside-modifying enzymes.

Front Pharmacol · 2022 · PMC9637796 · PMID 36353502

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highly significantno p-value reported

A p value of 0.05 was considered significant, and a p value of 0.01 was considered highly significant. 3 Results 3.1 DHA27 had no direct antibacterial effect but it can increase the antibacterial activity of aminoglycosides in Pseudomonas aeruginosa The MIC of DHA27 was >1,024 μg/ml for PA standard strain, indicating that DHA27 had no direct antibacterial effect on PA.

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