Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through <i>in silico</i> and <i>in vitro</i> screening.

Front Pharmacol · 2022 · PMC9638114 · PMID 36353483

Europe PMC DOI

hedged sentence

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closest p

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boldest claim

The sentences

not quite significantno p-value reported

The effect of these hit compounds on HD was not quite significant from the energetic aspect, and the overall dynamic characteristics were similar to the conformations of known small-molecule complexes of PARP-1.

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