Structure and mechanism of the type I-G CRISPR effector.

There are no significant structural hits for this model within the protein data bank, but structural comparisons with the complete Swissprot database AF2 models using Foldseek ( 50 ) yielded a highly significant match to the predicted structure of the large Cas8a2 subunit of type I-A Cascade from Methanocaldococcus jannaschii and related archaea.

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There are of course likely to be significant structural changes on target DNA binding – as observed recently for the type I-C complex ( 9 ), but there is also scope for the Cas3 subunit to play a role in these processes.

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