The Mycobacterium tuberculosis Ku C-terminus is a multi-purpose arm for binding DNA and LigD and stimulating ligation.

Nucleic Acids Res · 2022 · PMC9638933 · PMID 36250639

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an overall trendno p-value reported

Interestingly, each purified Ku mutant had a statistically significant change in apparent K D compared to Ku WT alone, with an overall trend in increased affinity (Figure 3A – C , Supplementary Figure S8 ), with co-operativity maintained (Hill coefficient > 1).

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an interesting trendno p-value reported

We noticed an interesting trend in some of our results, where Ku min had a poorer outcome than Ku core .

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