Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy.

Front Immunol · 2022 · PMC9641621 · PMID 36389797

Europe PMC DOI

hedged sentence

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

borderline significantp=0.059so close (0.05 < p ≤ 0.1)

In 2 trials (MLSPZV1 (Mali 1) (Mali, 2014) and MLSPZV2 (Mali 2) (Mali, 2016)), antibody levels were significantly higher in protected vs unprotected males and in one additional trial (EGSPZV3 (Equatorial Guinea, 2018)) the difference was borderline significant (p=0.059).

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