Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats.

Nevertheless, IL-18 revealed an increasing trend corresponding to the health complications of the animals with the highest concentrations detected in the ZO group ( P < 0.05 in comparison with the control; Figure 6d ). 4 Discussion It is well known that diabetes plays a substantial role in testicular pathophysiology through inducing tubular atrophy, damage to the spermatogenic line, and alterations to the blood–testis barrier, which together with chronic inflammation and oxidative stress may contribute to a reduced sperm function [ 7 , 30 ].

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