a statistical trendp = 0.07
The 643 rare variants were significant in explaining changes in the HDRS score over time in burden ( T = 878.9; Φ = 89194.6; p = 0.0033) and SKAT-O tests ( p = 0.0069) and remission rates in the burden test ( T = -1974.1; Φ = 869281.1; p = 0.034), but not response rates, though a statistical trend was observed in the burden test ( T = −1773.9; Φ = 937912.7; p = 0.07) (see Table 3 ).