An Ideal Hallmark Closest to Complete Cure of Chronic Hepatitis B Patients: High-sensitivity Quantitative HBsAg Loss.

The dominant B cell epitopes (S76 and S78) in patients with negative HBsAg may be significant candidates for treatment to achieve a functional cure. 49 During PegIFNα treatment, the proportion of total B cells and plasma B cells in the HBsAg-negative group was higher than that in the HBsAg-positive group, when other factors including age, sex, and treatment duration were completely matched. 50 Durability of HBsAg seroclearance Functional cure is more reflected in the recovery of liver function, especially the specific immune function against HBV, through the maximum long-term suppression of HBV replication, without emphasis on the elimination of integrated HBV DNA and cccDNA.

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