Comparison between Ki-67 positive cell proportions in cisplatin-exposed organoids (20 μM, 144 h) and controls showed no significant difference, although there was a decreasing trend in positive cell proportions in the cisplatin-exposed organoids ( Fig. 4E ).
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Kidney organoid derived from renal tissue stem cells is a useful tool for histopathological assessment of nephrotoxicity in a cisplatin-induced acute renal tubular injury model.
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