Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.

Although the abundance of Clostridium was not significantly correlated with the TUDCA or NorDCA concentration ( R = −0.3141, P = 0.3734 and R = 0.3482, P = 0.3194, respectively), a highly significant negative correlation was found between the abundance of Clostridium and the primary bile acid CDCA ( R = −0.8398, P = 0.0040) (Fig. 4c ).

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