Time‑dependent changes in NLRP3 and Nrf2 levels in lipopolysaccharide‑induced acute lung injury.

1A , LPS induced pathological changes in the lung tissues of the mice at 4, 24, 48, 96 and 144 h when compared with the control group, and the highest lung injury scores were recorded from the LPS-4 h to LPS-96 h groups; the scores then exhibited a decreasing trend in the LPS-144 h group ( Fig. 1B ).

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Additionally, LPS exposure also resulted in the highest number of white blood cells (WBCs) compared with the control group, with a significant difference up to 96 h of LPS administration, with an increasing trend from 4 h ( Fig. 1C ).

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