Expression levels of NONO, a nuclear protein primarily involved in paraspeckles function, are associated with several deregulated molecular pathways and poor clinical outcome in multiple myeloma.

Interestingly, the functional annotation analysis of this signature, aimed at identifying highly significant represented categories, revealed the enrichment in biological processes like proteasome-mediated protein catabolism, mitotic spindle organization, ncRNA metabolic process, and double-strand break repair (Supplementary Fig.

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