Sex-Based Differences in the Association between Serum Copper and Kidney Function: Evidence from NHANES 2011-2016.

In males, there was an association of the highest Cu quartile with decreased eGFR (β = −0.023, 95% CI: −0.042 to −0.003) and increased UACR (β = 0.349, 95% CI: 0.171 to 0.527); serum Cu levels also demonstrated a negative nonlinear dose–response association with eGFR and a positive linear dose–response association with UACR in males, whereas females showed a marginally significant nonlinear positive association of eGFR with serum Cu levels.

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