Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.

Int J Mol Sci · 2022 · PMC9656774 · PMID 36362151

Europe PMC DOI

hedged sentence

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

marginal significancep = 0.051so close (0.05 < p ≤ 0.1)

There was no change in RAD51 expression and a slight decrease in CHK1 in all BRCA1 clones, but only reaching marginal significance in BRCA1 exon-9.2 ( p = 0.051).

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