Interactive contribution of hyperinsulinemia, hyperglycemia, and mammalian target of rapamycin signaling to valvular interstitial cell differentiation and matrix remodeling.

Front Cardiovasc Med · 2022 · PMC9661395 · PMID 36386326

Europe PMC DOI

hedged sentences

0.0005

closest p · 0.0× alpha

0.0780

boldest claim

The sentences

highly significantp = 0.0005actually significant

Comparison between rapamycin and HI treatment revealed opposed effects with highly significant difference ( p = 0.0005; Figure 5A ).

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a slight trendp = 0.078so close (0.05 < p ≤ 0.1)

Combined treatment of rapamycin with HG or HG + HI conditions led to a slight trend toward lower ELN gene expression in comparison to NG control conditions ( p = 0.078).

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