The role of KRAS splice variants in cancer biology.

Front Cell Dev Biol · 2022 · PMC9663995 · PMID 36393833

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highly significantno p-value reported

This highly significant finding establishes for the first time a direct effect of RAS on metabolism, represents the first demonstration of a biochemical difference between KRAS splice variants, and suggests a unique vulnerability for KRAS driven cancers that express oncogenic KRAS4A.

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