Specifically, NFATc1 activation led to a highly significant and reproducible induction of proinflammatory cytokines (eg, Ccrl2 and Ccl5 ) and chemokines (eg, Cxcl2, Cxcl9 Cxcl10, Cxcl11), inflammatory transcription factors (eg, Stat1 and S tat2 ) and cell death marker genes (eg, Bak1 , Casp7 and Tnfsf10 ) ( figure 5D ).
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NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression.
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