Thiazide Diuretics and Fracture Risk: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

JBMR Plus · 2022 · PMC9664541 · PMID 36398110

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a nonsignificant trendno p-value reported

Two trials reported a significant increase in BMD for at least one anatomical site (LaCroix, total hip ( 28 ) ; Giles, lumbar spine ( 51 ) ), while the two other trials ( 47 , 52 ) reported a nonsignificant trend toward increased BMD with thiazide use.

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