Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition.

JCO Precis Oncol · 2022 · PMC9666117 · PMID 36331239

Europe PMC DOI

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highly significantP = 8.6 × 10 –308actually significant

In independent prespecified validation, the MA-PRS was a highly significant predictor of BC, after accounting for family cancer history, in the overall cohort (OR per standard deviation, 1.43; 95% CI, 1.40 to 1.46; P = 8.6 × 10 –308 ) and within each self-reported ancestry (Table 2 ).

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