Role of RAS signaling in ovarian cancer.

e different histological subtypes with respect to their frequency of occurrence. 68 , 69 Moreover, KRAS mutation has been a common event in many histotypes of OC. 70 , 71 RAS mutations in OC Reports from previous studies confirm that the mutational status of KRAS shows an increasing trend from normal ovaries (0%) to benign mucinous ovarian tumors (BMOT) (57%), mucinous borderline ovarian tumors (MBOT) (90%), and mucinous OC (MOC) (76%) signifying its key involvement in the succession of benign tumors to aggressive OC. 72 In OC, KRAS mutations are observed in codons 12, 13, a

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