Estimating the sample size of sham-controlled randomized controlled trials using existing evidence.

F1000Res · 2022 · PMC9669514 · PMID 36451658

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a small trendno p-value reported

This can be also attributed to the overoptimistic expected effect sizes in individual trials and to a small trend of increase in the intervention effect over time, possibly because of a learning curve effect in performing the specific procedure.

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