Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.

Specifically, unlike MTX alone, combination treatment induced a highly significant increase of CD45 + cells, NK cells, DCs, TAM1, monocytes, neutrophils and CD11b + and CD103 + DC subsets compared to control mice in both tumor models (Fig. 5 F-H and Supplementary Fig.

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