Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

When analysing 500 bp upstream regions using melanoma WGS data, we found that the TERT promoter stood out as highly significant ( q = 1.3 × 10 −6 ), and that TTCCG-related hotspot mutations were markedly absent among the top results using our approach (Fig. 3a , Supplementary Data 4 ).

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