highly significantP < 0.01
The differences between groups were considered statistically significant at * P < 0.05 and highly significant at ** P < 0.01, *** P < 0.001, and **** P < 0.0001.
The differences between groups were considered statistically significant at * P < 0.05 and highly significant at ** P < 0.01, *** P < 0.001, and **** P < 0.0001.