Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy.

For comparisons with borderline significant or trending P values based on a P < 0.05 cutoff, the sample size was suitable at 60% to 70% power using α = 0.05.

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Small changes due to TRPC6 inhibition might be missed, but we believe in the setting of the controlled design used here; such smaller differences are likely less important to the overall biology than larger ones and mortality benefits, which were highly significant.

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