Characteristics of lymphocyte subset alterations in COVID-19 patients with different levels of disease severity.

We found that in comparison with the mild COVID-19 patients, there was an obvious trend of a decrease in immature NK-cell number in severe patients ( p < 0.01), and a notable reduction in critical patients ( p < 0.0001).

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In 584 COVID-19 patients, the IL-6 levels showed an increasing trend with increasing disease severity, it is worth noting that the IL-6 values were concentrating in normal level in mild COVID-19 patients, while it was markedly increasing in critical patients (Fig. 5 E).

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The other T lymphocyte subset counts showed a decreasing trend with increasing IL-6 levels (Fig. 5 A).

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