Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability.

For example, when considering all VPA-exposed pups versus unexposed pups (All-E versus All-N), among the set of genes downregulated by VPA we observed highly significant enrichment for terms relating to glutamate receptor complex (FDR = 9.74 × 10 −12 ), regulation of membrane potential (FDR = 0), synapse assembly (FDR = 2.17 × 10 −11 ), post-synaptic membrane (FDR = 2.11 × 10 −4 ), neurotransmitter receptor activity (FDR = 2.33 × 10 −4 ) and axon guidance (FDR = 0).

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