Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans.

Elife · 2022 · PMC9681199 · PMID 36412098

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highly significantno p-value reported

For instance, we have shown that XCI-skew does not correlate with other cellular and molecular markers of biological ageing, nor indeed that frailty, smoking nor obesity are risk factors, and these results we feel are highly significant findings.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.