highly significantp<0.001
Correlation analysis of MMP-9/BDNF ratio with parameters of interest for the clinical assessment of the disease severity ( Table 4 ) revealed its negative correlation with IL-10/IL-17 ratio in moderately ill patients (p<0.05) and highly significant positive correlation with MMP-8 in mild (I), moderate (II) and IV (critical) groups (p<0.001).