A pleiotropic hypoxia-sensitive <i>EPAS1</i> enhancer is disrupted by adaptive alleles in Tibetans.

We find a highly significant departure from the expectation that the mean blunting score is equal to zero (two-tailed one-sample t test P < 2.2 × 10 −16 ), demonstrating that deletion of ENH5 results in a transcriptome-wide dampening of the response to sustained hypoxia ( Fig. 3E ).

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