Barely Significant
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Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Nat Commun · 2022 · PMC9684486 · PMID 36418293

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highly significantno p-value reported
Consistent with aberrations in the maintenance and formation of synapses, the M489V mice displayed a small but highly significant reduction in spine density in hippocampal neurons.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.