Follow-up of the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228).

EFSA J · 2022 · PMC9685353 · PMID 36440381

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a decreasing trendno p-value reported

The levels of plasma‐S‐sulfonate and levels of TBARS and 4‐HNE in retina and brain increased in a dose‐dependent manner, while GSH and GSSG levels showed a decreasing trend with increasing doses of sodium metabisulfite.

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