Integrin α6β4 signals through DNA damage response pathway to sensitize breast cancer cells to cisplatin.

These data revealed that, compared to the knockdown of integrin α6β4 or p53 alone, the effect of knockdown of both mutant p53 and integrin β4 ( Figure 1H ) on cell viability in response to cisplatin is additive ( Figure 1G ; p = 0.03) and highly significant (p < 0.0001 vs control at 1μM and 2.5μM).

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