Unsupervised Analysis Based on DCE-MRI Radiomics Features Revealed Three Novel Breast Cancer Subtypes with Distinct Clinical Outcomes and Biological Characteristics.

Remarkably, we found that tumor shape features, such as surface volume ratio and least axis length, showed extremely significant differences among the three imaging subtypes in both cohorts ( p -value < 0.001, Figure 3 a,b).

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The imaging features that can reflect dynamic enhanced characteristics of the tumor, including the medians of early PE and late SER maps, demonstrated highly significant differences among imaging subtypes in both cohorts ( p -value < 0.05, Figure 3 c,d).

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