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In Vitro and Ex Vivo Evaluation of Fluocinolone Acetonide-Acitretin-Coloaded Nanostructured Lipid Carriers for Topical Treatment of Psoriasis.

Gels · 2022 · PMC9689900 · PMID 36421568

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a decreasing trendno p-value reported
Because the amount of lipid available to accept increased drug concentrations could be insufficient, a decreasing trend in the %EE was observed with the increasing drug concentration beyond a certain limit.

also in 47,180 other papers

an increasing trendno p-value reported
When the concentration of solid lipid was decreased, an increasing trend was observed in the %EE.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.