Because the amount of lipid available to accept increased drug concentrations could be insufficient, a decreasing trend in the %EE was observed with the increasing drug concentration beyond a certain limit.
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In Vitro and Ex Vivo Evaluation of Fluocinolone Acetonide-Acitretin-Coloaded Nanostructured Lipid Carriers for Topical Treatment of Psoriasis.
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The sentences
When the concentration of solid lipid was decreased, an increasing trend was observed in the %EE.