Polygenic risk scores: An overview from bench to bedside for personalised medicine.

(2012) derived a PRS from five highly significant SNPs to improve predictions when used in combination with clinical risk factors, compared to clinical risk factors alone.

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Lastly, the GIFT trial, which is the largest and most recent warfarin pharmacogenomics trial, assessed perioperative warfarin dosing and reported a decrease in a composite clinical outcome using the pharmacogenomic dosing algorithm, driven mostly by a reduction in episodes of INR >4 and a borderline significant reduction in major bleeding ( Gage et al., 2017 ).

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